Renkin San-kyuu Magical? Pokaan chronicles the daily occurrences in the lives of four extraordinary young ladies: Liru the werewolf, Uma the witch, Aiko the android, and Pachira the vampire- all of whom hold royal status from the underworld. Their quest to find a new abode brings them to the perplexing human world, where they grapple with understanding societal standards and routines. In their frivolous pursuits, they inadvertently wreak havoc and fall under the radar of Dr. K-Ko, a scientist who perceives them as a threat and wishes to research them. Every day presents new trials and tribulations as they try to comprehend the sinister intent of Dr. K-Ko and navigate the marvels of human civilization.