Tsunayoshi Sawada lacks many desirable qualities, making him an unlikely match for anyone. He lacks coordination, skills, and struggles to win over beautiful Kyouko Sasagawa, who is well above his league. Scorned by peers, he’s deemed “Loser Tsuna,” and as a middle schooler, he feels like the embodiment of failure itself. However, one fateful encounter with a peculiar hitman named Reborn takes Tsuna’s mundane existence on an unexpected turn. Reborn is an Italian Mafia member from the most powerful clan, charged with the task of grooming Tsuna into replacing the retiring ninth boss of the notorious Vongola family. Although the journey ahead is daunting, with the assistance of his new criminal cohorts and his peculiar home teacher, even Loser Tsuna could possibly achieve greatness.