The odd and ominous creatures referred to as Mushi were initially perceived as peculiar and dreaded by humans. Despite their lack of malicious intent, Mushi's unusual characteristics often lead to harmful consequences and unplanned outcomes. It is therefore of utmost importance to approach Mushi respectfully and with understanding to prevent catastrophes and strife. Mushishi Zoku Shou trails the journey of Mushishi Ginko as he assists the visible world in peaceful coexistence with Mushi. In his travels, Ginko encounters a variety of people with unique capacities, some of whom are plagued by ill-fate while others maintain an intricate equilibrium with Mushi. This begs the question of whether humanity, with all its complexities and hardships, can handle the weight of managing the unseen. As a Mushishi, Ginko must delve deeper into his comprehension of these mysterious creatures and contemplate whether or not he should intervene in the intricate relations between Mushi and humankind.