Masane Amaha and her daughter Rihoko are fleeing from a government child welfare agency that desires to separate them. Sadly, they are apprehended and Rihoko is taken away. Simultaneously, Masane is ambushed by a sophisticated weapon that can masquerade as a person. When danger looms, a mysterious radiance emanates from her wrist, transforming her into a potent force. She obliterates the weapon, thrusting her into a battle for authority between dominant associations, which turn their focus towards her. Her possession of the supreme power, the legendary Witchblade, places her at the center of it all.