The lives of humans are still being altered by the enigmatic and ancient beings known as Mysterious Mushi. Ginko, a wandering Mushishi, continues to strive towards resolving the unsettling situations that he encounters. Mushi interference can result in a range of effects, including time loops, telepathy, and obscure phenomena that may take years to surface, all of which concern Ginko as he journeys from one village to another. Despite the fact that Ginko has been thrust into the role of an adjudicator, distinguishing between Mushi that are beneficial and those that are harmful, his judgments are subjective. Some of his patients prefer to take pleasure in their newfound powers until they are consumed by them, whilst others desperately struggle to rid themselves of their Mushi afflictions, which often serve to protect them from devastation. Those who come into contact with Mushi must learn to accept seemingly impossible consequences and address internal wounds they were previously unaware of, or face fates that they cannot comprehend.