In 1939, the world suffered severe devastation caused by the unexplained extraterrestrial weaponry known as the "Neuroi," leaving behind ruins. Traditional weapons proved ineffective against the invincible attacks, making it challenging for humanity to defend themselves. To even the playing field, resistance forces required an advanced solution. This is where the "Striker Unit" came in - a device that transformed the magical abilities of young girls into deadly weapons. These women, called "Witches," united across the world, with the 501st Joint Fighter Wing leading the charge to battle for human survival in the "Strike Witches" campaign.