Upon transferring to a new all-girls school, Kanako Miyamae's heart yearned for true love. However, fate had a different plan in store for her in the form of Mariya Shidou, a stunning classmate she encountered on her first day. The catch? Mariya is actually a cross-dressing boy. Forced to share a room with him after uncovering his secret, Kanako's life took a turn for the worse with constant interference from the cruel Mariya and his sharp-tongued maid, Matsurika Shinouji. Despite the obstacles in her path, Kanako remained determined to find her soulmate. This pursuit, coupled with the struggles of high school, continue in Maria†Holic Alive.