The Layton Detective Agency, run by Katrielle Layton - the daughter of the famous archaeology professor Hershel Layton - specializes in solving peculiar mysteries. Together with her assistant Noah Montoir and her trusty canine companion, Sherl, Katrielle sets out on a quest to unravel anomalous cases, such as a newly acquired cursed property, a gown with a "demonic curse," and the revival of a former client's deceased partner. In addition to her quirky undertakings, Katrielle also focuses her attention on uncovering the truth behind her father's disappearance. Establishing her agency was the first step in unlocking the mystery of her father's vanishing. As she navigates through a series of unusual cases, Katrielle moves closer to solving the greatest enigma of her life.