Nicholas Brown and Worick Arcangelo, known as the "Handymen," take on dangerous contracts for both mob syndicates and law enforcement in Ergastalum. Their current task is to take out a local pimp, but they enlist the help of Alex Benedetto, a prostitute who is also a target. As they work together, they realize that a new underground group is targeting "Twilights," individuals with heightened abilities from a specific drug. This endangers the stability of the city, and the Handymen must prepare for an inevitable conflict.