The new era of demonic presence has emerged, anticipated by the dying Dr. Faust. Unable to personally combat this impending peril, he places his trust in a young boy named Shingo Yamada to rid the world of this malevolent force. Upon discovering a birthmark on Shingo's forehead identifying him as the chosen warrior against demons, Faust summons Mephisto, a devil whose willingness to help is lacking. In a pact sealed with blood, Shingo and Mephisto undertake the daunting task of fighting against the supernatural realm, humanity's sole chance for survival.