Contrary to popular belief, the renowned detective Holmes doesn't employ deductive reasoning to solve mysteries. Rather, his expertise lies in his ability to track down blood-sucking vampires. The brief episodes of Vampire Holmes narrate the adventures of Holmes and his assistant, who initially run a standard detective agency until they are commissioned by the undercover London Metropolitan Police to unearth the existence of vampires. However, Holmes' claim is far from factual. He and his partner, Hudson, often engage in fruitless arguments and struggles to crack cases. Accompanied by Kira, a slightly demonic feline, and their landlord who is motivated by rent, this is the record of a man who was undeniably not London's finest investigator.