The manga "Ai Mai Mii" was adapted into an anime series featuring four-panel compositions. The story revolves around the manga club members Ai, Mai, Mii, and Ponoka-senpai as they face absurd challenges, such as fighting hostile extraterrestrials intending to annihilate Earth or participating in tournaments against skilled rivals. Aside from these oddball trials, they encounter humorous predicaments while not engaged in crafting manga.