Touta Konoe grew up as an ordinary kid in a quaint rural town. But his humdrum existence takes a sudden turn when his mentor, Yukihime, unveils herself as a vampire. After rescuing him from almost certain death, she grants Touta immortality too. With a deep yearning to explore the world, the young boy decides to pursue his lifelong ambition of reaching the apex of Amanomihashira, a tower that leads to outer space. On his journey, he discovers a clandestine group of fellow immortals, known as "UQ Holders". With the help of new allies and guidance from his mentor, Touta embarks on a personal and spellbinding odyssey.