Set in the mid-1800s, this tale unveils the journey of a young doctor, Ryo-an Tezuka, who has honed his skills in the Western-style medicine, and a young samurai, Manjiro Ibutani, who strives to uphold the ancient traditions of his social class and culture. Interestingly, the story is derived from real-life characters, with Ryo-an being the great grandfather of Tezuka. Against the backdrop of the chaotic end of the Tokugawa Period, the two contrasting personalities of Ibutani, a low-ranked samurai with superior swordsmanship and firm values of justice, and Tezuka, a cheerful heartthrob with an unwavering passion for medicine, find themselves coming of age. The events in the Second Year of Ansei, in the Koishigawa district of Edo, will forever change their lives.