Anhe, a group of assassins renowned for their secrecy, is comprised of the Su, Xie, and Mu families. Poison has afflicted everyone, putting their lives in danger. This tragic news has led to an uprising among the three factions of the Anhe River. Su Muyu, the leader of the Spider Shadow bodyguards, has recruited the gifted doctor Bai Hehuai from Medicine King Valley to heal the elders while also defending Elder Zhouquan from attackers. At the same time, Su Changhe, a friend of Su Muyu's within Anhe, has chosen to participate in the mission to assassinate the patriarch on behalf of the Su clan.