The "Anarchy Sisters" go by the names Panty and Stocking, having been kicked out of Heaven for their troublesome ways. They get their shot at retribution by helping Garterbelt, a priest, clear out the ghosts in Daten City. Their approach involves turning their undergarments into deadly weapons, although they rarely take their duties seriously. Instead, Panty pursues erotic liaisons with anyone available, while Stocking indulges her sweet tooth. Follow these unpredictable angels as they fight ghosts, endure bodily fluid mishaps, and try not to get sidetracked in Panty & Stocking with Garterbelt.