Kakashi Hatake, Naruto Uzumaki, Sakura Haruno, and Sai were assigned to investigate the sudden disappearance of four formidable ninjas from various countries. Eventually, they came across the missing individuals and reported the information to the Hokage. However, their efforts were abruptly disrupted by Hiruko, a former Konohagakure ninja who was obsessed with power. Hiruko had absorbed the unique abilities of the missing ninjas and sought one more bloodline limit to become invincible and initiate a global war for world domination. As suspicions spread across the nations about the involvement of Konohagakure, Tsunade was given an ultimatum to resolve the crisis. Unable to come up with an alternative solution, she decided to follow Kakashi's risky plan, even if it meant putting his life in jeopardy. However, Naruto vehemently opposed the plan and was determined to rescue his mentor, no matter the consequences, even if it meant battling against friends and foes alike.