Sho Fukamachi, an average adolescent, stumbles upon an extraterrestrial artifact known as Unit by chance, which transforms his life indefinitely. Upon bonding with Sho, the Unit gives birth to an immensely dominant entity called Guyver. Empowered by this new strength, Sho combats the inexplicable Chronos organization and its Zoanoids in a crusade to safeguard his loved ones and the planet. Unbeknownst to him, battling Chronos will reveal the genesis of humanity, their fate, and their creators.