The Elric brothers' alchemy experiment ended in tragedy, leaving them in a nightmare realm. Against the principle forbidding human transmutation, they attempted to revive their deceased mother, but it resulted in irreversible damage: Alphonse's body disintegrated, while Edward sacrificed an arm and leg to anchor his brother's soul to a metal suit. Pinako Rockbell and her granddaughter Winry rescued them. Using her bio-mechanical engineering talent, Winry equipped Edward with automail, a durable metal used for robots and armor. The brothers set out to regain their forms by searching for the Philosopher's Stone - a gem that defies the laws of Equivalent Exchange. As Edward gains notoriety as "Fullmetal" and sharpens his alchemy skills, they become enmeshed in a vast conspiracy jeopardizing the world's destiny.