In the early 1930s, the Flying Pussyfoot, a transcontinental train, sets off from Chicago and leaves a deadly trail across the country. At the same time, scientist Szilard and his unwilling accomplice Ennis scour New York for missing vials of an immortality elixir. The mafia groups grow increasingly volatile amidst the chaos. Additionally, in 1711, the Advena Avis, a vessel, exposes the catastrophic cost of immortality. From light novels, Baccano! tells an intricate story of alchemy, survival, and eternal life. At first glance, the narrative seems disjointed. However, it connects characters from differing eras and locations, such as Isaac and Miria, optimistic and aspiring thieves. Their actions significantly impact everyone, creating long-lasting connections and consequences.