In each episode, Nuku Nuku, the android companion of young Kyuusaku Natsume, sets out on various adventures and challenges throughout high school. However, the show's overarching plot delves into the sinister ambitions of Mishima Industries, which are aimed at achieving global domination by means of their products. Joining forces against this nefarious scheme, the slightly eccentric Kyuusaku Natsume and Nuku Nuku partner up. All of Nuku Nuku's classmates are eccentric characters, from the over-assertive class president, Futaba, to the snobbish Chieko Shirakaba and her two loyal followers. Moreover, there is a bookworm, mystic, scientist, and pop singer, each of whom perfectly embodies their respective roles. The mystic employs occult methods to predict doom, and the pop singer communicates exclusively through singing, among other unique traits which contribute to the show's comedic elements.