With tensions escalating between the magical realm and Academy City, it's up to Touma Kamijou and his negation abilities to defend those in his circle against both espers and magicians. But he's not alone, new and old allies and enemies will step forward to join the fray, fighting by his side or against him from the shadows. In Toaru Majutsu no Index II, the action-comedy tale continues to unfold on an even grander scale as the looming conflict draws closer, pitting magic against science once more.