An entire city is destroyed by two monstrously powerful beings. Genzou Kuruma, who is both a scientist and a leader of a sect, has a dream of awakening God, but needs a very specific type of blood to make it happen. Luckily, his son Shinichi Kuruma, and a young girl named Ayaka Sanders, have this blood. However, Genzou is willing to go to any lengths to obtain it, even if it means the complete destruction of humanity. While trying to avoid Genzou's genetically-modified "New Humans," which have the ability to turn into monsters, Shinichi, Ayaka, and Tomizoro ("Tommy") must devise a plan to seek vengeance against Genzou. Shinichi is one of the "New Humans," and like the rest of them, can summon beasts from his own body. He will use this power to defeat Genzou and get revenge for the misdeeds of his father.