Despite appearing as one of the prettiest girls in school, Shuuichi Nitori, a fifth-grader, is actually biologically male, rendering him effeminate. His friend Yoshino Takatsuki, a lanky tomboy, shares a comparable unease regarding gender identity, despite being biologically female. Together, the two confidants find comfort in each other's secrets. However, their circumstances become more complicated when they transfer to a new school, making it challenging to build new relationships while trying to maintain old ones. Navigating their way through growing up, transgenderism, intimacy, and acceptance proves to be an arduous task as they enter puberty. Takako Shimura's Hourou Musuko is applauded as a powerful and authentic perspective for portraying LGBT experiences and gender identity.