Many idolize supermodel Fudo Jun for her beauty, but she is oblivious to a dark secret within her. Her genes hold the next stage in the evolution of mankind - the same blood as the beastlike superhumans that ravage the city. Although unlike the rest of them, Jun has managed to maintain a fragile grip on her humanity. Asuka Ran, a member of a government organization shrouded in mystery, recruits her to join them in controlling and, possibly, exterminating these destructive beings. Jun, now Devilman Lady, must eliminate her own kind, but her sanity may not hold up in a situation thrust upon her without her consent.