The desolate wasteland of Earth is a result of the Gamilas Empire's planet bombs, leaving humanity seeking refuge underground in 2199 due to the radiation. However, hope for the planet remains with the Cosmo Reverse System from Iscandar, possessing the power to restore the surface. In a last-ditch effort, the Earth Defense Force has put all its resources into the Yamato, a cutting-edge battleship operated by a range of individuals from tactical officer Susumu Kodai to seasoned Captain Juuzou Okita. Despite their differing backgrounds and roles, their mission is united - to embark on a perilous 168,000 light-year voyage to Iscandar and save humanity from impending doom.