While on a school trip in Taiwan, monsters unexpectedly assault Shio Ogura, a high schooler from Japan. In the face of the crisis, the DOGOO government organization deploys their "E-Gene Holders," who are equipped with weapons infused with the essence of renowned historical figures. Amidst the chaos, Shio discovers that she also possesses E-Gene Holder abilities after the safety of her friend triggers the spirit of Oda Nobunaga within her.