"Happy birthday, OOO!" ―Kousei Kougami during the trailer.[src] The year is 2021 and the world is in a state of chaos and fear. The ancient OOO has come back to life after 800 years of sleep. The ancient OOO has also resurrected the Greeeds, Uva, Kazari, Mezool and Gamel, who want to exterminate humanity and take over the world. Shintaro Goto and Akira Date, who once fought the Greeed, fight back as the resistance. Hina Izumi, Chiyoko Shiraishi and others support them. And Eiji Hino, who had gone on a trip, returned. However, the power of the ancient OOO is so great that humanity's inferiority cannot be shaken. Then, something happens to that "broken core medal", and Ankh is revived. On the other hand, the mysterious Greeed Goda is born from the artificial core medal. The situation becomes even more chaotic... What will be the fate of Eiji and Ankh? Now, the battle of the kings for the survival of mankind begins.......!