Joutarou Kuujou is peacefully imprisoned in Japan with no criminal charges against him. He believes that he is possessed by an evil spirit that can harm those around him, and insists that he not be released. Holly Kuujou is worried about her son and asks her father, Joseph Joestar, to persuade Joutarou to leave the prison. Joseph reveals that Joutarou's "evil spirit" is actually a "Stand," a physical representation of one's fighting spirit that can take on various deadly forms. After a violent altercation with Joseph's acquaintance, Mohammed Avdol, Joutarou is freed from jail and begins to learn how to manage the power of his Stand. However, an awakening Stand inside Holly is poised to destroy her in just 50 days. Joutarou, his grandfather, and their companions must locate and eradicate an immortal vampire who is responsible for her illness. Along the way, they confront fierce Stand users who are determined to hinder their mission. If they fail, humanity will face a bleak future, making their journey to Cairo, Egypt even more crucial.