"Iczelion" marks a deviation from the previous plotline in numerous ways, serving as the final installment in the "Icz" saga. Across the cosmos, two ruthless antagonists by the names of Cross and Chaos sweep through everything in their path, ravaging and destroying. Now, their sights are set on their next conquest: Earth. In response, the Iczelions emerge as the sole line of defense - a fusion of young girls and sentient body armor known as Iczels. Nagisa, an average high school student, is thrust into the role of an Iczelion against her will; her mission: to defend the planet and safeguard humanity's future. However, she's determined to fight back and has no intention of succumbing to destiny's whims.