In A.D. 2010, a sudden shift in the environment and an unknown contaminant caused a rapid and devastating loss of all men. The population dwindled to unimaginable lows, leaving only women to navigate an overgrown and re-colonized world. These women now huddle together in small pockets of civilization, striving to exist amidst constant struggle and debate. While some have come to terms with the inevitability of their doomed fate and live a carefree life, others are fiercely dedicated to continuing the human race via scientific means. These opposing ideals lead to tension and strife, with conflicting principles and policies ever-present in their society. The center of this tale lies in Tokyo, one of the few remaining bastions of survival. Here, a fierce conflict over the "ICE" specimen and its potential to save humanity ignites, marking a turning point in their fight for survival.