Relocating to a new school and forging new relationships can be a daunting task, especially for Bocchi Hitori as she transitions from elementary to middle school. Her extreme social anxiety takes a toll on her, causing her to faint under stress, vomit when anxious, and make extensive plans to evade social situations. Unfortunately, Bocchi's only friend from elementary, Kai Yawara, won't be accompanying her in middle school. Moreover, Kai ends their friendship to motivate Bocchi to make peace with her classmates after befriending everyone in her new class. Despite her lack of self-confidence, Bocchi is determined to reignite her friendship with Kai and make friends with every individual in her class. Summoning her courage, she takes the first step towards socializing with the tough-looking girl seated in front of her...