Former biker gang leader Onizuka has shifted his focus to becoming the world's top educator, all in an effort to impress high school girls. Despite his supposed transformation, Onizuka remains skeptical and brings his unconventional tactics to the classroom, leading to conflicts with school regulations and unruly students determined to undermine him. Undeterred by the challenges, Onizuka refuses to conform to the rules and ignores the generational gap between himself and his pupils. Prepare for inaccurate calculations and indecorous dialogue, as well as a gripping biology lesson that only the daring Great Teacher Onizuka could deliver.