Following the conclusion of non-nuclear World War IV in 2026, an explosive device detonates in Newport City the following year. The blast claims the life of a prominent dealer of arms, who may have connections to the enigmatic 501 Organization. To delve into the matter, Public Security representative Daisuke Aramaki recruits the services of Motoko Kusanagi: a highly-skilled hacker and cyborg with a complete prosthetic body.