The protagonist of Doujin Work, Najimi Osana, delves into the doujin world, initially drawn in by a friend's lucrative earnings at a convention. Despite her passion for drawing, she soon discovers that this new realm is much more challenging than anticipated. However, as she attends more events and encounters new acquaintances, Najimi befriends a fascinating group of individuals who possess some background in doujin creations. They offer their support and guidance, propelling her towards her ultimate goal of becoming a renowned doujinshi artist.