Yuu and Nobu are practicing their two-person comedic act, Manzai, on the rooftop of their school, completely unaware of the otherworldly beings that reside within. These entities possess the power to transform humans into their own kind, leading to devastating attacks. As chaos ensues, the crucial question remains: can Yuu, Nobu, and their companions outrun the grasp of these aggressive creatures? It's worth mentioning that a special OVA edition, titled Alice in Deadly School Special Edit - The Stage Begins, premiered on January 4th, 2021, as a part of the New Year's festivities.